Yes. Mucosae are involved in almost all patients with Stevens Johnson Syndrome /Toxic Epidermal Necrolysis —not only those with extensive cutaneous manifestations. In fact, mucosal lesions may precede skin lesions. Preferential sites include the oropharynx and esophagus, tracheobronchial tree, GI tract, genitalia, and anus. Painful oral erosions cause severe crusting of the lips, increased salivation, and impaired alimentation. Intact expectorated cylindrical casts of bronchial epithelium may also occur, and involvement of genitalia can lead to painful micturition. Patients with GI manifestations often develop a profuse proteinrich
diarrhea. Of all mucosal lesions, the most problematic are the ocular ones, since they often leave
sequelae. Initially, the conjunctivae are erythematous and painful, with lids often stuck together. Efforts to
loosen them may result in tearing of the epidermis. Eventually, pseudomembranous conjunctival erosions
form synechiae between the eyelids and conjunctivae, with inverted eyelashes, keratitis, corneal erosions, and corneal/conjunctival neovascularization.
diarrhea. Of all mucosal lesions, the most problematic are the ocular ones, since they often leave
sequelae. Initially, the conjunctivae are erythematous and painful, with lids often stuck together. Efforts to
loosen them may result in tearing of the epidermis. Eventually, pseudomembranous conjunctival erosions
form synechiae between the eyelids and conjunctivae, with inverted eyelashes, keratitis, corneal erosions, and corneal/conjunctival neovascularization.