Pathology definition - Carcinoma Of The Cervix
Carcinoma of the cervix or cervical carcinoma can be divided into different stages such as cervical dysplasia, cervical carcinoma in situ and invasive carcinoma of the cervix.
The stages of progression to carcinoma of the cervix may begin initially with cervical dysplasia, cervical carcinoma in situ and finally into squamous cell carcinoma of the cervix. Pap smear is performed to identify any progression in the carcinoma of the cervix.
Cervical dysplasia is characterized by scan cytoplasm, hyperchromatic nuclei which involves the squamocolumnar junction. There will be growth of epithelium form the basal layer which later extend outward. Cervical dysplasia is categorized into cervical intraepithelial neoplasia grade I, II and III. Cervical intraepithelial neoplasia grade I ( CIN I) is present with atypical undifferentiated cells in the lower third of the epithelium. Cervical intraepithelial neoplasia grade II ( CIN II) may present with atypical undifferentiated cell in 1/3 - 2/3 thickness of the epithelium. Cervical intraepithelial neoplasia grade III ( CIN III) may present with more than 2/3 thickness of the epithelium.
Cervical carcinoma in situ may present without any invasion of the basement membrane which is characterized with dysplastic cells that extend through the entire epithelium.
Patient with invasive cervical carcinoma may present with dysuria, ulceration of the cervix, postcoital bleeding, irregular bleeding of the vagina and non purulent discharge.Invasive cervical carcinoma may present mostly as keratinized squamous cell carcinoma and adenocarcinoma . Invasive cervical carcinoma may arises form cervical intraepithelial neoplasia. Invasive cervical carcinoma may present ulcerating, exophytic or infiltrating mass on the cervix.
Carcinoma of the cervix is associated with multiple sexual partner and the early age of intercourse. Carcinoma of the cervix may occur due to human papilloma virus type 16, 18 31 and 33. The treatment will focus hysterectomy and radiotherapy.
The stages of progression to carcinoma of the cervix may begin initially with cervical dysplasia, cervical carcinoma in situ and finally into squamous cell carcinoma of the cervix. Pap smear is performed to identify any progression in the carcinoma of the cervix.
Cervical dysplasia is characterized by scan cytoplasm, hyperchromatic nuclei which involves the squamocolumnar junction. There will be growth of epithelium form the basal layer which later extend outward. Cervical dysplasia is categorized into cervical intraepithelial neoplasia grade I, II and III. Cervical intraepithelial neoplasia grade I ( CIN I) is present with atypical undifferentiated cells in the lower third of the epithelium. Cervical intraepithelial neoplasia grade II ( CIN II) may present with atypical undifferentiated cell in 1/3 - 2/3 thickness of the epithelium. Cervical intraepithelial neoplasia grade III ( CIN III) may present with more than 2/3 thickness of the epithelium.
Cervical carcinoma in situ may present without any invasion of the basement membrane which is characterized with dysplastic cells that extend through the entire epithelium.
Patient with invasive cervical carcinoma may present with dysuria, ulceration of the cervix, postcoital bleeding, irregular bleeding of the vagina and non purulent discharge.Invasive cervical carcinoma may present mostly as keratinized squamous cell carcinoma and adenocarcinoma . Invasive cervical carcinoma may arises form cervical intraepithelial neoplasia. Invasive cervical carcinoma may present ulcerating, exophytic or infiltrating mass on the cervix.
Carcinoma of the cervix is associated with multiple sexual partner and the early age of intercourse. Carcinoma of the cervix may occur due to human papilloma virus type 16, 18 31 and 33. The treatment will focus hysterectomy and radiotherapy.
