Pharmacology definition - Anti Emetic Agents
Anti Emetic Agents
There are few forms of anti emetic agents such as prochlorperazine, metoclopramide and ondansetron. These anti emetic agents are useful in treating patient nausea and vomiting after surgery or in case of chemotherapy induced nausea and vomiting.
Ondansetron will block 5 HT3 receptors. 5HT3 receptors present in the brainstem at the chemoreceptor trigger zone ( vomiting reflex pathway) and in the lining of the gastrointestinal tract. In normal circumstance the 5HT 3 receptors will be activated from the release of the serotonin from the damaged by enterochromaffin cells. A signal will be sent to the brainstem through vagus nerve which activates the vomiting reflex pathway. The common side effects of ondansetron is headache.
Metoclopramide will acts as dopamine antagonist. Metoclopramide will prevent activation of D2 receptors which present at the chemoreceptor trigger zone which lead to inactivation of the vomiting reflex pathway. The common side effects of metoclopramide may include diarrhea, sedation and extrapyramidal symptoms.
Prochlorperazine may also acts as dopamine antagonist for D2 receptors. The common side effects of prochlorperazine are sedation, extrapyramidal symptoms and hypotension.
There are few forms of anti emetic agents such as prochlorperazine, metoclopramide and ondansetron. These anti emetic agents are useful in treating patient nausea and vomiting after surgery or in case of chemotherapy induced nausea and vomiting.
Ondansetron will block 5 HT3 receptors. 5HT3 receptors present in the brainstem at the chemoreceptor trigger zone ( vomiting reflex pathway) and in the lining of the gastrointestinal tract. In normal circumstance the 5HT 3 receptors will be activated from the release of the serotonin from the damaged by enterochromaffin cells. A signal will be sent to the brainstem through vagus nerve which activates the vomiting reflex pathway. The common side effects of ondansetron is headache.
Metoclopramide will acts as dopamine antagonist. Metoclopramide will prevent activation of D2 receptors which present at the chemoreceptor trigger zone which lead to inactivation of the vomiting reflex pathway. The common side effects of metoclopramide may include diarrhea, sedation and extrapyramidal symptoms.
Prochlorperazine may also acts as dopamine antagonist for D2 receptors. The common side effects of prochlorperazine are sedation, extrapyramidal symptoms and hypotension.
