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Pathology definition - Membranoproliferative glomerulonephritis

Membranoproliferative glomerulonephritis
Membranoproliferative glomerulonephritis may present as type I membranoproliferative glomerulonephritis and type II membranoproliferative glomerulonephritis. Membranoproliferative glomerulonephritis is associated with inherited deficiency of the component of the complement. Commonly patient is under 30 years old
Type I membranoproliferative glomerulonephritis may present with hyperlipidemia, proteinuria, edema and hypoalbuminemia ( nephrotic syndrome). Type I membranoproliferative glomerulonephritis may be treated with antiplatelet drugs and corticosteroid. Type I membranoproliferative glomerulonephritis may present with expansion of the mesangial matrix into the capillary loop /tram track appearance and reduplication of the basement membrane. There will be electron dense deposition on the subendothelium. The common cause of type I membranoproliferative glomerulonephritis are hepatitis B, hepatitis C and SLE.
Type II membranoproliferative glomerulonephritis may present with hematuria. Type II membranoproliferative glomerulonephritis is best treated with antiplatelet drug and corticosteroid. Homogenous material will be densely deposit within the glomerular basement membrane. Type II membranoproliferative glomerulonephritis may also present with expansion of the mesangial matrix into the capillary loop /tram track appearance and reduplication of the basement membrane.The complication of type II membranoproliferative glomerulonephritis may include chronic renal failure
References
1.Gans, Reinold O., and Leonard G. Feld. "Membranoproliferative Glomerulonephritis Type 1." New England Journal of Medicine 334.6 (1996): 367-367.
2.Appel, Gerald B., et al. "Membranoproliferative glomerulonephritis type II (dense deposit disease): an update." Journal of the American Society of Nephrology 16.5 (2005): 1392-1403.
Membranoproliferative glomerulonephritis may present as type I membranoproliferative glomerulonephritis and type II membranoproliferative glomerulonephritis. Membranoproliferative glomerulonephritis is associated with inherited deficiency of the component of the complement. Commonly patient is under 30 years old
Type I membranoproliferative glomerulonephritis may present with hyperlipidemia, proteinuria, edema and hypoalbuminemia ( nephrotic syndrome). Type I membranoproliferative glomerulonephritis may be treated with antiplatelet drugs and corticosteroid. Type I membranoproliferative glomerulonephritis may present with expansion of the mesangial matrix into the capillary loop /tram track appearance and reduplication of the basement membrane. There will be electron dense deposition on the subendothelium. The common cause of type I membranoproliferative glomerulonephritis are hepatitis B, hepatitis C and SLE.
Type II membranoproliferative glomerulonephritis may present with hematuria. Type II membranoproliferative glomerulonephritis is best treated with antiplatelet drug and corticosteroid. Homogenous material will be densely deposit within the glomerular basement membrane. Type II membranoproliferative glomerulonephritis may also present with expansion of the mesangial matrix into the capillary loop /tram track appearance and reduplication of the basement membrane.The complication of type II membranoproliferative glomerulonephritis may include chronic renal failure
References
1.Gans, Reinold O., and Leonard G. Feld. "Membranoproliferative Glomerulonephritis Type 1." New England Journal of Medicine 334.6 (1996): 367-367.
2.Appel, Gerald B., et al. "Membranoproliferative glomerulonephritis type II (dense deposit disease): an update." Journal of the American Society of Nephrology 16.5 (2005): 1392-1403.