Surgery Definition – What is Gardner Syndrome?
Surgery Definition – What is Gardner Syndrome?
Gardner Syndrome is considered as polyposis of the colon transformation into the carcinoma of the colon with demoplastic tendency of the fibrous tissue. Gardner Syndrome is an autosomal dominant condition. Possibility of developing colon cancer at the age of 40. Consists of polyps covering the colon with the present of soft tissue tumor, tumors of the endocrine, abnormalities of the bone and medulloblastoma and abnormal dentition.
The patient with Gardner’s Syndrome may present with diarrhea, per rectum bleeding and vague cases of abdominal pain.
The investigation of Gardner’s Syndrome may include double contrast barium enema and colonoscopy, genetic screening for the present of the mutation of the APC gene on chromosome 5q.
The treatment for the Gardner’s Syndrome may include subtotal colectomy with the formation of ileorectal anastomosis and the destruction of the rectal polyps. Follow up is required every 6 months for the remaining life of the patient to destroy the rectal polyps.
In case rectal cancer formation, abdominoperineal resection and permanent ileostomy is needed.
Alternative treatment may include prophylactic panproctocolectomy may be performed.
The screening may include annual sigmoidoscopy for first degree relvative from puberty until formation of the adenoma or even when there are negative for APC gene mutation in genetic screening. If genetic screening is not available, consider annual sigmoidoscopy until 25 years of age and every 2 years until the age of 35.
Gardner Syndrome is considered as polyposis of the colon transformation into the carcinoma of the colon with demoplastic tendency of the fibrous tissue. Gardner Syndrome is an autosomal dominant condition. Possibility of developing colon cancer at the age of 40. Consists of polyps covering the colon with the present of soft tissue tumor, tumors of the endocrine, abnormalities of the bone and medulloblastoma and abnormal dentition.
The patient with Gardner’s Syndrome may present with diarrhea, per rectum bleeding and vague cases of abdominal pain.
The investigation of Gardner’s Syndrome may include double contrast barium enema and colonoscopy, genetic screening for the present of the mutation of the APC gene on chromosome 5q.
The treatment for the Gardner’s Syndrome may include subtotal colectomy with the formation of ileorectal anastomosis and the destruction of the rectal polyps. Follow up is required every 6 months for the remaining life of the patient to destroy the rectal polyps.
In case rectal cancer formation, abdominoperineal resection and permanent ileostomy is needed.
Alternative treatment may include prophylactic panproctocolectomy may be performed.
The screening may include annual sigmoidoscopy for first degree relvative from puberty until formation of the adenoma or even when there are negative for APC gene mutation in genetic screening. If genetic screening is not available, consider annual sigmoidoscopy until 25 years of age and every 2 years until the age of 35.
