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Pathology definition - Osler Weber Rendu Syndrome
Osler Weber Rendu Syndrome
Osler Weber Rendu Syndrome may present with signs and symptoms such as hemorrhage form lesion of the mucous membrane ( gastrointestinal tract, respiratory tract, oral cavity and urinary tract) and skin. Osler Weber Rendu syndrome is associated with dilation of the venules and capillaries as well as convolution of the venules and the capillaries mostly of the skin and the mucous membrane of the gastrointestinal tract, respiratory tract, oral cavity and urinary tract.
Olser Weber Rendu Sydnrome is an autosomal dominant condition due to mutation that affects the tumor growth factor beta. ( TGF - beta). Laboratory investigation may reveal normochromic anemia.
The treatment of Osler Weber Rendu syndrome may include treatment of epistaxis ( epistaxis is nose bleeding and the main complication of the Osler Weber Rendu syndorme). The treatment may include nasal packing and cautery. Estrogen may be useful to control epistaxis. Other complication of Osler Weber Rendu syndrome may include gastrointestinal bleeding.
References
1.Morphet, John A.M. “Osler-Weber-Rendu Syndrome.” CMAJ: Canadian Medical Association Journal 175, no. 10 (November 7, 2006): 1243. doi:10.1503/cmaj.1060182.
2.Haitjema T, Westermann CJ, Overtoom TC, and et al. “Hereditary Hemorrhagic Telangiectasia (osler-Weber-Rendu Disease): New Insights in Pathogenesis, Complications, and Treatment.” Archives of Internal Medicine 156, no. 7 (April 8, 1996): 714–719. doi:10.1001/archinte.1996.00440070028004.
Osler Weber Rendu Syndrome may present with signs and symptoms such as hemorrhage form lesion of the mucous membrane ( gastrointestinal tract, respiratory tract, oral cavity and urinary tract) and skin. Osler Weber Rendu syndrome is associated with dilation of the venules and capillaries as well as convolution of the venules and the capillaries mostly of the skin and the mucous membrane of the gastrointestinal tract, respiratory tract, oral cavity and urinary tract.
Olser Weber Rendu Sydnrome is an autosomal dominant condition due to mutation that affects the tumor growth factor beta. ( TGF - beta). Laboratory investigation may reveal normochromic anemia.
The treatment of Osler Weber Rendu syndrome may include treatment of epistaxis ( epistaxis is nose bleeding and the main complication of the Osler Weber Rendu syndorme). The treatment may include nasal packing and cautery. Estrogen may be useful to control epistaxis. Other complication of Osler Weber Rendu syndrome may include gastrointestinal bleeding.
References
1.Morphet, John A.M. “Osler-Weber-Rendu Syndrome.” CMAJ: Canadian Medical Association Journal 175, no. 10 (November 7, 2006): 1243. doi:10.1503/cmaj.1060182.
2.Haitjema T, Westermann CJ, Overtoom TC, and et al. “Hereditary Hemorrhagic Telangiectasia (osler-Weber-Rendu Disease): New Insights in Pathogenesis, Complications, and Treatment.” Archives of Internal Medicine 156, no. 7 (April 8, 1996): 714–719. doi:10.1001/archinte.1996.00440070028004.
