Pharmacology definition - Phenoxybenzamine
Phenoxybenzamine is useful prior to surgery in patient with pheochromocytoma to prevent hypertensive crisis. Phenoxybenzamine is also useful in treating patient with chronic non resectable pheochromocytoma.
Phenoxybenzamine will act as irreversible alpha receptor antagonist which prefer alpha 1 receptor. Phenoxybenzamine will cause reduction in the blood pressure by inhibiting the activation of the alpha receptor which lead to decrease in vasoconstriction.
The common side effects of phenoxybenzamine are tachycardia, orthostatic hypotension, ejaculation inhibition and nasal congestion.