Pharmacology definition - Hydrochlorothiazide
Hydrochlorothiazide is useful in treating patient with nephrogenic diabetic insipidus, cardiac failure, hypertension and kidney stone ( calcium stone).
Hydrochlorothiazide ( chlorthalidone, metolazone and chlorothiazide) may inhibit the Na+/ CI- co transporter in the distal convoluted tubule of the nephron. As a result there will be an increase in the renal loss of water and salt due to retention of the water and sodium chloride in the lumen of the tubule.
Hydrochlorothiazide may lead to an increase the secretion of potassium ions and sodium ions with decrease secretion of the calcium ion in the urine. Hydrochlorothiazide may lead to hyperglycemia, hypercalcemia, hypokalemia, hyperuricemia, hyperlipidemia and metabolic acidosis.