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Pathology definition - Kaposi Sarcoma
Kaposi Sarcoma
Kaposi sarcoma is common disorder that is associated with AIDS and immune disorders. Kaposi sarcoma commonly present as a result of dilation of the blood vessel as a result of mononuclear infiltrate into the endothelium. This will be identified later histopathologically as the present of hemosiderin pigment, spindle cells, hyaline globules and mitotic process.
Kaposi sacroma may be divided into a few variants. The first variant of kaposi sarcoma include classic kaposi sarcoma, endemic /african kaposi sarcoma and epidemic kaposi sarcoma. Classic kaposi sarcoma commonly affecting older men of mediterranean origin.
Endemic kaposi sarcoma mostly affecting african men and children. Epidemic kaposi sarcoma mostly present in patient who suffer from AIDS/HIV patient due to its relation to the human herpes virus type 8.
Kaposi sarcoma may present with erythematous macule which later progress into red- purple,raised, painless plaque which finally form the nodules. Other common signs and symptoms may include abdominal pain, cough, shortness of breath and edematous lesions.
Kaposi sarcoma will be detected by the present of the specific KSHV antibodies. The treatment of kaposi sarcoma may include series of chemotherapy which consists of vincristine, doxorubicin, alpha interferon and vinblastine. Other treatments include radiotherapy and reduction in the HIV viral load.
References
1.Beral, V., T. A. Peterman, R. L. Berkelman, and H. W. Jaffe. “Kaposi’s Sarcoma among Persons with AIDS: A Sexually Transmitted Infection?” The Lancet 335, no. 8682 (January 20, 1990): 123–128. doi:10.1016/0140-6736(90)90001-L.
2.Cesarman, E., R. G. Nador, K. Aozasa, G. Delsol, J. W. Said, and D. M. Knowles. “Kaposi’s Sarcoma-Associated Herpesvirus in Non-AIDS Related Lymphomas Occurring in Body Cavities.” The American Journal of Pathology 149, no. 1 (July 1996): 53–57.
3.Monini, Paolo, Antonella Rotola, Laura de Lellis, Alfredo Corallini, Paola Secchiero, Adriana Albini, Roberto Bennelli, Carlo Parravicini, Giuseppe Barbanti-Brodano, and Enzo Cassai. “Latent BK Virus Infection and Kaposi’s Sarcoma Pathogenesis.” International Journal of Cancer 66, no. 6 (1996): 717–722. doi:10.1002/(SICI)1097-0215(19960611)66:6<717::AID-IJC1>3.0.CO;2-2.
Kaposi sarcoma is common disorder that is associated with AIDS and immune disorders. Kaposi sarcoma commonly present as a result of dilation of the blood vessel as a result of mononuclear infiltrate into the endothelium. This will be identified later histopathologically as the present of hemosiderin pigment, spindle cells, hyaline globules and mitotic process.
Kaposi sacroma may be divided into a few variants. The first variant of kaposi sarcoma include classic kaposi sarcoma, endemic /african kaposi sarcoma and epidemic kaposi sarcoma. Classic kaposi sarcoma commonly affecting older men of mediterranean origin.
Endemic kaposi sarcoma mostly affecting african men and children. Epidemic kaposi sarcoma mostly present in patient who suffer from AIDS/HIV patient due to its relation to the human herpes virus type 8.
Kaposi sarcoma may present with erythematous macule which later progress into red- purple,raised, painless plaque which finally form the nodules. Other common signs and symptoms may include abdominal pain, cough, shortness of breath and edematous lesions.
Kaposi sarcoma will be detected by the present of the specific KSHV antibodies. The treatment of kaposi sarcoma may include series of chemotherapy which consists of vincristine, doxorubicin, alpha interferon and vinblastine. Other treatments include radiotherapy and reduction in the HIV viral load.
References
1.Beral, V., T. A. Peterman, R. L. Berkelman, and H. W. Jaffe. “Kaposi’s Sarcoma among Persons with AIDS: A Sexually Transmitted Infection?” The Lancet 335, no. 8682 (January 20, 1990): 123–128. doi:10.1016/0140-6736(90)90001-L.
2.Cesarman, E., R. G. Nador, K. Aozasa, G. Delsol, J. W. Said, and D. M. Knowles. “Kaposi’s Sarcoma-Associated Herpesvirus in Non-AIDS Related Lymphomas Occurring in Body Cavities.” The American Journal of Pathology 149, no. 1 (July 1996): 53–57.
3.Monini, Paolo, Antonella Rotola, Laura de Lellis, Alfredo Corallini, Paola Secchiero, Adriana Albini, Roberto Bennelli, Carlo Parravicini, Giuseppe Barbanti-Brodano, and Enzo Cassai. “Latent BK Virus Infection and Kaposi’s Sarcoma Pathogenesis.” International Journal of Cancer 66, no. 6 (1996): 717–722. doi:10.1002/(SICI)1097-0215(19960611)66:6<717::AID-IJC1>3.0.CO;2-2.
