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Pathology definition - Medulloblastoma
Medulloblastoma
Medulloblastoma is a malignant tumor that present as well circumscribed gray tumor in the midline of the cerebellum. Patient with medulloblastoma may present with signs and symptoms such as nausea, vomiting, headaches, raised intracranial pressure,unsteady gait and obstructive hydrocephalus. 5 years survival rates will increase with total surgical excision and radiotherapy.
Medulloblastoma commonly affecting children due to deletion of the short arm chromosome 17p. Pathologically there will be a sheets of anaplastic cells. These anaplastic cells may present with hyperchromatic nuclei, mitoses and scant cytoplasm. The anaplastic cells are arranged in perivascular pseudorosette formation or in rosette formation.
The current treatment of medulloblastoma may include surgical excision, radiotherapy and chemotherapy.
References
1.Jozwiak, Jaroslaw, Wieslawa Grajkowska, and Pawel Wlodarski. “Pathogenesis of Medulloblastoma and Current Treatment Outlook.” Medicinal Research Reviews 27, no. 6 (2007): 869–890. doi:10.1002/med.20088.
2.Provias, John Peter, and Laurence Edward Becker. “Cellular and Molecular Pathology of Medulloblastoma.” Journal of Neuro-Oncology 29, no. 1 (July 1, 1996): 35–43. doi:10.1007/BF00165516.
Medulloblastoma is a malignant tumor that present as well circumscribed gray tumor in the midline of the cerebellum. Patient with medulloblastoma may present with signs and symptoms such as nausea, vomiting, headaches, raised intracranial pressure,unsteady gait and obstructive hydrocephalus. 5 years survival rates will increase with total surgical excision and radiotherapy.
Medulloblastoma commonly affecting children due to deletion of the short arm chromosome 17p. Pathologically there will be a sheets of anaplastic cells. These anaplastic cells may present with hyperchromatic nuclei, mitoses and scant cytoplasm. The anaplastic cells are arranged in perivascular pseudorosette formation or in rosette formation.
The current treatment of medulloblastoma may include surgical excision, radiotherapy and chemotherapy.
References
1.Jozwiak, Jaroslaw, Wieslawa Grajkowska, and Pawel Wlodarski. “Pathogenesis of Medulloblastoma and Current Treatment Outlook.” Medicinal Research Reviews 27, no. 6 (2007): 869–890. doi:10.1002/med.20088.
2.Provias, John Peter, and Laurence Edward Becker. “Cellular and Molecular Pathology of Medulloblastoma.” Journal of Neuro-Oncology 29, no. 1 (July 1, 1996): 35–43. doi:10.1007/BF00165516.
