Surgery Definition – What is malignant hyperpyrexia?
Surgery Definition – What is malignant hyperpyrexia?
Malignant hyperpyrexia may present with symptoms and signs such as rigidity of the masseter muscle and generalized muscles, hypoxia, acidosis and rhabdomyolysis which caused by defect in the sarcoplasmic reticulum calcium release channel that affect the stability of the calcium homeostasis. Suxamethonium and halothane are common drugs which lead to malignant hyperpyrexia.
The treatment of malignant hyperpyrexia may include high flow of oxygen, external cooling, considered arterial blood gasses (ABG) for detection of acidosis, urea and electrolytes as well as creatine kinase. Calcium antagonist in the form of Dantrolene is administered. Cooled intravenous fluid is given for case of hypotension. Any cases of ventricular dysrhythmias are treated with procainamide. Anti convulsant is considered for case of seizures which are common.
Malignant hyperpyrexia may present with symptoms and signs such as rigidity of the masseter muscle and generalized muscles, hypoxia, acidosis and rhabdomyolysis which caused by defect in the sarcoplasmic reticulum calcium release channel that affect the stability of the calcium homeostasis. Suxamethonium and halothane are common drugs which lead to malignant hyperpyrexia.
The treatment of malignant hyperpyrexia may include high flow of oxygen, external cooling, considered arterial blood gasses (ABG) for detection of acidosis, urea and electrolytes as well as creatine kinase. Calcium antagonist in the form of Dantrolene is administered. Cooled intravenous fluid is given for case of hypotension. Any cases of ventricular dysrhythmias are treated with procainamide. Anti convulsant is considered for case of seizures which are common.
