Pharmacology definition - Monoamine Oxidase Inhibitor
Monoamine oxidase inhibitor.
Monoamine oxidase inhibitor will block the action of the monamine oxidase which is a presynaptic enzyme. Monamine oxidase will metabolize serotonin, norepinephrine and dopamine.
There are two form of monoamine oxidase. These are monoamine oxidase A which metabolizes norepinephrine and serotonin and monoamine oxidase B which metabolizes doapmine. Monoamine oxidase inhibitor will inhibit both monoamine oxidase A and monoamine oxidase B. Selegiline will selectively inhibit monoamine oxidase B. Selegiline will raise dopamine and is useful as adjunct for treatment of Parkinson’s disease.
Monoamine oxidase inhibitor such as isocarboxazid, phenelzine and tranylxypromine may then lead to an increase in the level of norepinephrine, serotonin and dopamine in the presynaptic neuron.
Monoamine oxidase inhibitor is useful in treating panic disorder, phobias or atypical form of depression. However monoamine oxidase inhibitor may also lead to hypertensive crisis. Hypertensive crisis is associated with reaction of monoamine oxidase inhibitor which inhibit metabolism of tyramine. Tyramine will build up in the gut which later lead to the release of norepinephrine and epinephrine which lead to headache, cardiac arrhythmias and hypertension.
Other sides effects of monoamine oxidase inhibitor include blurred vision, hypotension, sedation and gain in weight.
Monoamine oxidase inhibitor will block the action of the monamine oxidase which is a presynaptic enzyme. Monamine oxidase will metabolize serotonin, norepinephrine and dopamine.
There are two form of monoamine oxidase. These are monoamine oxidase A which metabolizes norepinephrine and serotonin and monoamine oxidase B which metabolizes doapmine. Monoamine oxidase inhibitor will inhibit both monoamine oxidase A and monoamine oxidase B. Selegiline will selectively inhibit monoamine oxidase B. Selegiline will raise dopamine and is useful as adjunct for treatment of Parkinson’s disease.
Monoamine oxidase inhibitor such as isocarboxazid, phenelzine and tranylxypromine may then lead to an increase in the level of norepinephrine, serotonin and dopamine in the presynaptic neuron.
Monoamine oxidase inhibitor is useful in treating panic disorder, phobias or atypical form of depression. However monoamine oxidase inhibitor may also lead to hypertensive crisis. Hypertensive crisis is associated with reaction of monoamine oxidase inhibitor which inhibit metabolism of tyramine. Tyramine will build up in the gut which later lead to the release of norepinephrine and epinephrine which lead to headache, cardiac arrhythmias and hypertension.
Other sides effects of monoamine oxidase inhibitor include blurred vision, hypotension, sedation and gain in weight.
