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Pathology definition - Guillain Barre Syndrome
Guillain Barre Syndrome
Guillain Barre syndrome may present with symptoms and signs such as ascending muscle weakness and paralysis which begin in the distal part of the lower limbs. Besides that patient may also present with dysregulation of the autonomic system, absent of the deep tendon reflexes, facial diplegia and loss of sensation in the extremities.
Guillain Barre syndrome may present with infiltration of the perivenular and endoneurial with macrophages and lymphocytes as well as segment of demyelination of the peripheral nerves.
Guillain Barre syndrome is treated with supportive care as well as plasmapheresis therapy. The main complication of Guillain Barre syndrome is respiratory failure.
Guillain Barre syndrome is associated with viral illness ( flu like) which induced T cell mediated reaction which later cause the demyelination of the peripheral nerves.
Lumbar puncture may reveal the present of albumino - cytologic dissociation of CSF. This will shows an increase in protein content with mild increase in cell count.
References
1.Winer, J. B. “Guillain Barré Syndrome.” Molecular Pathology 54, no. 6 (December 1, 2001): 381–385. doi:10.1136/mp.54.6.381.
2.Kuwabara, Satoshi. “Guillain-Barré Syndrome.” Current Neurology and Neuroscience Reports 7, no. 1 (January 1, 2007): 57–62. doi:10.1007/s11910-007-0022-6.
Guillain Barre syndrome may present with symptoms and signs such as ascending muscle weakness and paralysis which begin in the distal part of the lower limbs. Besides that patient may also present with dysregulation of the autonomic system, absent of the deep tendon reflexes, facial diplegia and loss of sensation in the extremities.
Guillain Barre syndrome may present with infiltration of the perivenular and endoneurial with macrophages and lymphocytes as well as segment of demyelination of the peripheral nerves.
Guillain Barre syndrome is treated with supportive care as well as plasmapheresis therapy. The main complication of Guillain Barre syndrome is respiratory failure.
Guillain Barre syndrome is associated with viral illness ( flu like) which induced T cell mediated reaction which later cause the demyelination of the peripheral nerves.
Lumbar puncture may reveal the present of albumino - cytologic dissociation of CSF. This will shows an increase in protein content with mild increase in cell count.
References
1.Winer, J. B. “Guillain Barré Syndrome.” Molecular Pathology 54, no. 6 (December 1, 2001): 381–385. doi:10.1136/mp.54.6.381.
2.Kuwabara, Satoshi. “Guillain-Barré Syndrome.” Current Neurology and Neuroscience Reports 7, no. 1 (January 1, 2007): 57–62. doi:10.1007/s11910-007-0022-6.