Pharmacology definition - Procainamide
Procainamide is useful in treating patient with ventricular tachycardia, atrial fibrillation and atrial flutter. Procainamide is sue dependent. Procainamide will be active in ions channel which are depolarizing frequently.
Procainamide/ class IA anti arrhythmic agent will bind and inhibit the activated sodium channel. Class IA anti arrhythmic agent will block the inflow of sodium ions into the cardiac myocyte. This will lead to prolongation of the phase 0 depolarization of the cardiac action potential. This will reduce the rate of conduction of the action potential and reducing the cardiac muscle contraction rates. Class IA anti arrhythmic agent may also cause a delay in the phase 3 repolarization( prolongation of the PR interval) due to interaction of the class IA anti arrhythmic agent with potassium channel. There will be a longer refractory period of the cardiac myocyte.
The common side effects of procainamide may include psychosis and drug induced lupus. Other forms of class IA anti arrhythmic agent such as disopyramide may lead to constipation, double vision and urinary retention while quinidine may lead to psychosis, tinnitus, vertigo, headache and gastrointestinal discomfort.
Procainamide/ class IA anti arrhythmic agent will bind and inhibit the activated sodium channel. Class IA anti arrhythmic agent will block the inflow of sodium ions into the cardiac myocyte. This will lead to prolongation of the phase 0 depolarization of the cardiac action potential. This will reduce the rate of conduction of the action potential and reducing the cardiac muscle contraction rates. Class IA anti arrhythmic agent may also cause a delay in the phase 3 repolarization( prolongation of the PR interval) due to interaction of the class IA anti arrhythmic agent with potassium channel. There will be a longer refractory period of the cardiac myocyte.
The common side effects of procainamide may include psychosis and drug induced lupus. Other forms of class IA anti arrhythmic agent such as disopyramide may lead to constipation, double vision and urinary retention while quinidine may lead to psychosis, tinnitus, vertigo, headache and gastrointestinal discomfort.
