Surgery Definition - What is muscle relaxant?
What is muscle relaxant?
There are two types of muscle relaxant such as depolarizing muscle relaxant and non depolarizing muscle relaxant. The depolarizing muscle relaxant include suxamethonium. Suxamethonium works by mimicking the action of acetylcholine at the neuromuscular junction. This will lead to depolarization.However, it will not hydrolysed by acetylcholinesterase as acetylcholine. Suxamethonium will undergoes slower process of metabolism by plasma pseudocholinesterase. This may lead to paralysis as a result of blockage of neuromuscular block which is prolonged in nature. Suxamethonium may lead to side effect such as hyperkalemia in cases of patient with deficient in pseudo cholinesterase. However, suxamethonium has its own advantages in the forms of rapid onset of action and short duration of action which make it easy to be used in emergency condition for crash induction as it facilitates intubation.
The common examples of non depolarizing muscle relaxant are vercuronium, atracurium and pancuronium. The non depolarizing muscle relaxant works by competing with acetylcholine for the receptor sites which located at the site of the motor end plate but may not lead to any cases of depolarization. The advantages of non depolarizing muscle relaxant include slower onset of actin with longer duration of action which make non depolarizing muscle relaxant more beneficial and suitable for long operation. However, the effect of non depolarizing muscle relaxant can be reversed with neostigmine which is the form of anticholinesterase.
There are two types of muscle relaxant such as depolarizing muscle relaxant and non depolarizing muscle relaxant. The depolarizing muscle relaxant include suxamethonium. Suxamethonium works by mimicking the action of acetylcholine at the neuromuscular junction. This will lead to depolarization.However, it will not hydrolysed by acetylcholinesterase as acetylcholine. Suxamethonium will undergoes slower process of metabolism by plasma pseudocholinesterase. This may lead to paralysis as a result of blockage of neuromuscular block which is prolonged in nature. Suxamethonium may lead to side effect such as hyperkalemia in cases of patient with deficient in pseudo cholinesterase. However, suxamethonium has its own advantages in the forms of rapid onset of action and short duration of action which make it easy to be used in emergency condition for crash induction as it facilitates intubation.
The common examples of non depolarizing muscle relaxant are vercuronium, atracurium and pancuronium. The non depolarizing muscle relaxant works by competing with acetylcholine for the receptor sites which located at the site of the motor end plate but may not lead to any cases of depolarization. The advantages of non depolarizing muscle relaxant include slower onset of actin with longer duration of action which make non depolarizing muscle relaxant more beneficial and suitable for long operation. However, the effect of non depolarizing muscle relaxant can be reversed with neostigmine which is the form of anticholinesterase.
