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Pathology definition - Colorectal adenocarcinoma
Colorectal adenocarcinoma
Colorectal adenocarcinoma is one of the commonest malignancy with high incidence of mortality. The treatment may include chemotherapy and surgical resection of the affected colon.
The patient may be asymptomatic . However, the patient may also present with symptoms and signs such as obstruction of the bowel, pain at the left lower quadrant, loss of weight, diarrhea intermittently and anemia ( iron deficiency anemia due to gastrointestinal bleeding).
Colorectal carcinoma may present as polypoid mass ( affecting the proximal part of the colon) or ulcerated irregular margin type of lesion which affect the distal part of the colon.
Tumor may be anaplastic in nature with dysplastic columnar and formation of the glandular with production of the mucin.
Laboratory investigation such as full blood count may reveal microcytic hypochromic anemia or raised in serum CEA ( tumor maker) and positive stool guaiac test.
Colorectal adenocarcinoma commonly affect the elderly ( around 60 -80 years of age). Patient usually initially suffer from long term cases of ulcerative colitis, multiple polyposis syndrome ( familial adenomatous polyposis, heriditary non polyposis colorectal cancer) and low fiber diets with the present of adenomatous polyps.
References
1.Compton, Carolyn C. “Colorectal Carcinoma: Diagnostic, Prognostic, and Molecular Features.” Modern Pathology 16, no. 4 (April 1, 2003): 376–388. doi:10.1097/01.MP.0000062859.46942.93.
2.Mecklin, Jukka-Pekka, Pentti Sipponen, and Dr Heikki J. Järvinen. “Histopathology of Colorectal Carcinomas and Adenomas in Cancer Family Syndrome.” Diseases of the Colon & Rectum 29, no. 12 (December 1, 1986): 849–853. doi:10.1007/BF02555362.
Colorectal adenocarcinoma is one of the commonest malignancy with high incidence of mortality. The treatment may include chemotherapy and surgical resection of the affected colon.
The patient may be asymptomatic . However, the patient may also present with symptoms and signs such as obstruction of the bowel, pain at the left lower quadrant, loss of weight, diarrhea intermittently and anemia ( iron deficiency anemia due to gastrointestinal bleeding).
Colorectal carcinoma may present as polypoid mass ( affecting the proximal part of the colon) or ulcerated irregular margin type of lesion which affect the distal part of the colon.
Tumor may be anaplastic in nature with dysplastic columnar and formation of the glandular with production of the mucin.
Laboratory investigation such as full blood count may reveal microcytic hypochromic anemia or raised in serum CEA ( tumor maker) and positive stool guaiac test.
Colorectal adenocarcinoma commonly affect the elderly ( around 60 -80 years of age). Patient usually initially suffer from long term cases of ulcerative colitis, multiple polyposis syndrome ( familial adenomatous polyposis, heriditary non polyposis colorectal cancer) and low fiber diets with the present of adenomatous polyps.
References
1.Compton, Carolyn C. “Colorectal Carcinoma: Diagnostic, Prognostic, and Molecular Features.” Modern Pathology 16, no. 4 (April 1, 2003): 376–388. doi:10.1097/01.MP.0000062859.46942.93.
2.Mecklin, Jukka-Pekka, Pentti Sipponen, and Dr Heikki J. Järvinen. “Histopathology of Colorectal Carcinomas and Adenomas in Cancer Family Syndrome.” Diseases of the Colon & Rectum 29, no. 12 (December 1, 1986): 849–853. doi:10.1007/BF02555362.
