Pathology definition - Polyarteritis Nodosa
Polyarteritis nodosa may present with signs and symptoms such as purpura palpable in nature,fever, malaise, nausea, vomiting, abdominal pain,hypertension, loss of weight, arthralgia, malaise. The complication of polyarteritis nodosa may include pericarditis and myocarditis.
Polyarteritis nodosa will affect small or medium muscular arteries. Polyarteritis nodosa is associated with hepatitis B virus infection. There will be fibrinoid necrosis with transmural inflammation of the arterial wall as a result of infiltration of mononuclear, eosinophil and neutrophil. Polyarteritis nodosa is the form of necrotizing vasculitis.
Laboratory investigation may reveal the present of leuckocytosis ( blood studies) and raised ESR level.
Polyarteritis nodosa mostly affecting middle age person. The treatment option of polyarteritis nodosa may include, azathioprine, cyclophosphamide and corticosteroids.
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2.Chen, K R. “Cutaneous Polyarteritis Nodosa: A Clinical and Histopathological Study of 20 Cases.” The Journal of Dermatology 16, no. 6 (December 1989): 429–442.