Pharmacology definition - Sulfonyureas
Sulfonyureas
Sulfonyureas is useful in treating patient with non insulin dependent type 2 diabetes mellitus .Sulfonyureas may react by increasing the action of insulin on targeted tissue by increasing the binding time of the insulin to the targeted tissue receptor. Sulfonyureas may also stimulate the secretion of the insulin from pancreas by inhibiting and blocking the potassium channel on the beta cells.
Sulfonyureas are contraindicated in hepatic insufficiency and renal insufficiency patient as the kidney and liver are unable to excrete sulfonyureas in this case.Sulfonyureas are contraindicated in pregnant women as it may cause depletion of the insulin in the pancreas of the fetal due to the ability of the sulfonyureas to pass cross the placenta.
There are two forms of sulfonyureas which are the first generation such as tolbutamide and second generation such as glipizide. The common side effects of sulfonyureas are allergic reaction, hypoglycemia and skin rash.
Sulfonyureas is useful in treating patient with non insulin dependent type 2 diabetes mellitus .Sulfonyureas may react by increasing the action of insulin on targeted tissue by increasing the binding time of the insulin to the targeted tissue receptor. Sulfonyureas may also stimulate the secretion of the insulin from pancreas by inhibiting and blocking the potassium channel on the beta cells.
Sulfonyureas are contraindicated in hepatic insufficiency and renal insufficiency patient as the kidney and liver are unable to excrete sulfonyureas in this case.Sulfonyureas are contraindicated in pregnant women as it may cause depletion of the insulin in the pancreas of the fetal due to the ability of the sulfonyureas to pass cross the placenta.
There are two forms of sulfonyureas which are the first generation such as tolbutamide and second generation such as glipizide. The common side effects of sulfonyureas are allergic reaction, hypoglycemia and skin rash.
