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Pathology definition - Anemia of Chronic Disease
Anemia of chronic disease
Chronic disease may itself cause anemia. Common chronic disease which lead to anemia may include malignancy (colorectal carcinoma), infection, connective tissue disorder ( SLE) and inflammatory disease ( inflammatory bowel disease such as Chron’s disease or ulcerative colitis and rheumatoid arthritis).
Anemia of chronic disease may present with signs and symptoms such as pallor and fatigue. However in most cases no treatment is required. Blood transfusion or erythropoietin is only considered in severe cases of anemia of chronic disease.
The investigations may include peripheral blood film and blood iron studies . Peripheral blood film/peripheral blood smear may reveal normochromic, normocytic erythrocytes while blood studies may reveal, low total iron binding capacity and low serum iron with decreased in the hematocrit. Ferritin may be elevated due to inflammatory reaction related to anemia of chronic disease
References
1.Sears, D A. “Anemia of Chronic Disease.” The Medical Clinics of North America 76, no. 3 (May 1992): 567–579.
2.Gr, Lee. “The Anemia of Chronic Disease.” Seminars in Hematology 20, no. 2 (April
Chronic disease may itself cause anemia. Common chronic disease which lead to anemia may include malignancy (colorectal carcinoma), infection, connective tissue disorder ( SLE) and inflammatory disease ( inflammatory bowel disease such as Chron’s disease or ulcerative colitis and rheumatoid arthritis).
Anemia of chronic disease may present with signs and symptoms such as pallor and fatigue. However in most cases no treatment is required. Blood transfusion or erythropoietin is only considered in severe cases of anemia of chronic disease.
The investigations may include peripheral blood film and blood iron studies . Peripheral blood film/peripheral blood smear may reveal normochromic, normocytic erythrocytes while blood studies may reveal, low total iron binding capacity and low serum iron with decreased in the hematocrit. Ferritin may be elevated due to inflammatory reaction related to anemia of chronic disease
References
1.Sears, D A. “Anemia of Chronic Disease.” The Medical Clinics of North America 76, no. 3 (May 1992): 567–579.
2.Gr, Lee. “The Anemia of Chronic Disease.” Seminars in Hematology 20, no. 2 (April
