Pathology definition - Primary Hyperparathyroidism
Primary hyperparathyroidism
Primary hyperparathyroidism may present with increased in the parathyroid hormone level, decreased in the serum phosphate, increased in alkaline phosphate and hypercalcemia. Patient may also present with weakness, peptic ulcer, nephrocalcinosis, osteitis fibrosa cystica ( pain in the bone) due to brown tumor ( fibrous tissue) in the cystic space as a result of increased in osteoclast activity.
Primary hyperparathyroidism may occur due to MEN 1 and MEN 11a, Parathyroid hormone adenoma/ parathyroid gland adenoma, ( parathyroid adenoma may present with circumscribed nodule with polygonal chief cells and oxyphil cells) parathyroid hormone hyperplasia ( parathyroid gland hyperplasia), carcinoma of the parathyroid gland / parathyroid hormone carcinoma and parathyroid like hormone secretion by tumor ( mostly due to bronchogenic carcinoma).
The treatment of primary hyperparathyroidism may include surgical removal of the abnormal glands.
Primary hyperparathyroidism may present with increased in the parathyroid hormone level, decreased in the serum phosphate, increased in alkaline phosphate and hypercalcemia. Patient may also present with weakness, peptic ulcer, nephrocalcinosis, osteitis fibrosa cystica ( pain in the bone) due to brown tumor ( fibrous tissue) in the cystic space as a result of increased in osteoclast activity.
Primary hyperparathyroidism may occur due to MEN 1 and MEN 11a, Parathyroid hormone adenoma/ parathyroid gland adenoma, ( parathyroid adenoma may present with circumscribed nodule with polygonal chief cells and oxyphil cells) parathyroid hormone hyperplasia ( parathyroid gland hyperplasia), carcinoma of the parathyroid gland / parathyroid hormone carcinoma and parathyroid like hormone secretion by tumor ( mostly due to bronchogenic carcinoma).
The treatment of primary hyperparathyroidism may include surgical removal of the abnormal glands.
