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Pathology definition - Buerger Disease
Buerger Disease
Buerger disease is also known as thromboangiitis obliterans. It is a form of segmental vasculitis. Buerger disease is commonly associated with smoking. Buerger disease may present with signs and symptoms such as intermittent claudication, Raynaud phenomenon, ulceration or gangrene of the extremities due to extreme ischemic attack. Patient may also present with superficial nodular phlebitis.
Buerger disease is common in men and the treatment usually focus on cessation of smoking or prevention of vasospasm by sympathectomy. Hispathologically there will be acute and chronic inflammatory infiltrate , formation of granulomatous lesion, microabscess, transmural inflammation and thrombosis of the vascular lumen.
Buerger disease typically affecting radial or tibial arteries ( small and medium sized peripheral arteries.) Buerger disease may also affect the veins.
References
1.Olin, Jeffrey W. “Thromboangiitis Obliterans (Buerger’s Disease).” New England Journal of Medicine 343, no. 12 (2000): 864–869. doi:10.1056/NEJM200009213431207.
2.Shionoya, S. “Buerger’s Disease: Diagnosis and Management.” Cardiovascular Surgery (London, England) 1, no. 3 (June 1993): 207–214.
Buerger disease is also known as thromboangiitis obliterans. It is a form of segmental vasculitis. Buerger disease is commonly associated with smoking. Buerger disease may present with signs and symptoms such as intermittent claudication, Raynaud phenomenon, ulceration or gangrene of the extremities due to extreme ischemic attack. Patient may also present with superficial nodular phlebitis.
Buerger disease is common in men and the treatment usually focus on cessation of smoking or prevention of vasospasm by sympathectomy. Hispathologically there will be acute and chronic inflammatory infiltrate , formation of granulomatous lesion, microabscess, transmural inflammation and thrombosis of the vascular lumen.
Buerger disease typically affecting radial or tibial arteries ( small and medium sized peripheral arteries.) Buerger disease may also affect the veins.
References
1.Olin, Jeffrey W. “Thromboangiitis Obliterans (Buerger’s Disease).” New England Journal of Medicine 343, no. 12 (2000): 864–869. doi:10.1056/NEJM200009213431207.
2.Shionoya, S. “Buerger’s Disease: Diagnosis and Management.” Cardiovascular Surgery (London, England) 1, no. 3 (June 1993): 207–214.
