Pediatric Definition - Glucose 6 Phosphate Dehydrogenase Deficiency
Glucose 6 Phosphate Dehydrogenase Deficiency
Glucose 6 phosphate dehydrogenase deficiency is an X linked disorder which are common in asian, african or mediterranean.
The infants may present with hyperbilirubinemia.Kernicterus is also common in infants. Oxidant stress may lead to asymptomatic children . Chronic hemolytic anemia may also occur with gallstones and splenomegaly.
The common symptoms and signs of glucose 6 phosphate dehydrogenase deficiency are cardiovascular compromise, pallor and jaundice.
The investigation requires may include hemoglobin level, reticulocyte counts and peripheral blood smear which reveals the present of bite cells and blister cells as well as reduction in the level of G6PD in erythrocytes.
The treatment of glucose 6 phosphate dehydrogenase may include red blood cell transfusion or avoidance of any medication such as sulfonamide, anti malarial agents or fava beans.
The differential diagnosis of glucose 6 phosphate dehydrogenase deficiency are autoimmune hemolytic anemia, hereditary spherocytosis, hypersplenism and hemoglobinopathies.
Glucose 6 phosphate dehydrogenase deficiency is an X linked disorder which are common in asian, african or mediterranean.
The infants may present with hyperbilirubinemia.Kernicterus is also common in infants. Oxidant stress may lead to asymptomatic children . Chronic hemolytic anemia may also occur with gallstones and splenomegaly.
The common symptoms and signs of glucose 6 phosphate dehydrogenase deficiency are cardiovascular compromise, pallor and jaundice.
The investigation requires may include hemoglobin level, reticulocyte counts and peripheral blood smear which reveals the present of bite cells and blister cells as well as reduction in the level of G6PD in erythrocytes.
The treatment of glucose 6 phosphate dehydrogenase may include red blood cell transfusion or avoidance of any medication such as sulfonamide, anti malarial agents or fava beans.
The differential diagnosis of glucose 6 phosphate dehydrogenase deficiency are autoimmune hemolytic anemia, hereditary spherocytosis, hypersplenism and hemoglobinopathies.
