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Pathology definition - Tumor of the gallbladder and biliary ducts
Tumor of the gallbladder and biliary ducts
Tumor of the gallbladder is known as adenocarcinoma of the gallbladder. Adenocarcinoma of the gallbladder is presented as diffuse thickening of the wall of the gallbladder with infiltrative pattern of growth.The will be a irregular cauliflower type of masses from the exophytic pattern of growth into the lumen of the gallbladder.Adenocarcinoma of the gallbladder may invade the liver and presented with varying degree of cell differentiation.
Gallbladder adenocarcinoma is commonly associated with gallstones and affecting women mostly 60 years of age. Patient with gallbladder adenocarcinoma may complain of symptoms and signs such as abdominal pain, jaundice, nausea, vomiting and anorexia ( symptoms and signs of gallstones).
Gallbladder carcinoma is best treated with cholecystectomy, radiotherapy and chemotherapy.
Biliary duct may present with extrahepatic biliary duct and ampulla of vater carcinoma. Pathologically the carcinoma is presented as gray nodules small in characteristic in the wall of the bile duct.There is also an epithelium proliferation,fibrous stroma and mucin secreting cells detected microscopically.
Carcinoma of the ampulla of vater and extrahepatic biliary duct commonly associated with elderly men, infection by Clonorchis sinesis, inflammatory bowel disease and primary sclerosing cholangitis.
Patient with carcinoma of the extrahepatic biliary duct and ampulla of vater may complain of loss of weight, nausea and vomiting, obstructive jaundice and painless but palpable enlarged bladder.
Extrahepatic biliary duct carcinoma is treated with chemotherapy and radiotherapy. It is not treatable with surgical resection. However carcinoma of the ampulla of vater is treated with surgical resection.
Gallbladder adenocarcinoma, carcinoma of the ampulla of vater and extrahepatic biliary duct carcinoma may affect the liver function and present with prolongation of the prothrombin time and raised in liver enzyme such as AST, ALP and ALT.
References
1.Sung, Joseph J. Y., and Yuk Tong Lee. “Tumors of the Biliary Tract.” In Atlas of Gastroenterology, edited by Tadataka Yamada MD President Adjunctessor, 606–614. Wiley-Blackwell, 2009.
2.Gassler, N, and R Knüchel. “[Tumors of Vater’s ampulla].” Der Pathologe 33, no. 1 (February 2012): 17–23. doi:10.1007/s00292-011-1546-8.
3.Von Kuster, Larry C., and Cynthia Cohen. “Malignant Mixed Tumor of the Gallbladder. Report of Two Cases and a Review of the Literature.” Cancer 50, no. 6 (1982): 1166–1170. doi:10.1002/1097-0142(19820915)50:6<1166::AID-CNCR2820500622>3.0.CO;2-L.
Tumor of the gallbladder is known as adenocarcinoma of the gallbladder. Adenocarcinoma of the gallbladder is presented as diffuse thickening of the wall of the gallbladder with infiltrative pattern of growth.The will be a irregular cauliflower type of masses from the exophytic pattern of growth into the lumen of the gallbladder.Adenocarcinoma of the gallbladder may invade the liver and presented with varying degree of cell differentiation.
Gallbladder adenocarcinoma is commonly associated with gallstones and affecting women mostly 60 years of age. Patient with gallbladder adenocarcinoma may complain of symptoms and signs such as abdominal pain, jaundice, nausea, vomiting and anorexia ( symptoms and signs of gallstones).
Gallbladder carcinoma is best treated with cholecystectomy, radiotherapy and chemotherapy.
Biliary duct may present with extrahepatic biliary duct and ampulla of vater carcinoma. Pathologically the carcinoma is presented as gray nodules small in characteristic in the wall of the bile duct.There is also an epithelium proliferation,fibrous stroma and mucin secreting cells detected microscopically.
Carcinoma of the ampulla of vater and extrahepatic biliary duct commonly associated with elderly men, infection by Clonorchis sinesis, inflammatory bowel disease and primary sclerosing cholangitis.
Patient with carcinoma of the extrahepatic biliary duct and ampulla of vater may complain of loss of weight, nausea and vomiting, obstructive jaundice and painless but palpable enlarged bladder.
Extrahepatic biliary duct carcinoma is treated with chemotherapy and radiotherapy. It is not treatable with surgical resection. However carcinoma of the ampulla of vater is treated with surgical resection.
Gallbladder adenocarcinoma, carcinoma of the ampulla of vater and extrahepatic biliary duct carcinoma may affect the liver function and present with prolongation of the prothrombin time and raised in liver enzyme such as AST, ALP and ALT.
References
1.Sung, Joseph J. Y., and Yuk Tong Lee. “Tumors of the Biliary Tract.” In Atlas of Gastroenterology, edited by Tadataka Yamada MD President Adjunctessor, 606–614. Wiley-Blackwell, 2009.
2.Gassler, N, and R Knüchel. “[Tumors of Vater’s ampulla].” Der Pathologe 33, no. 1 (February 2012): 17–23. doi:10.1007/s00292-011-1546-8.
3.Von Kuster, Larry C., and Cynthia Cohen. “Malignant Mixed Tumor of the Gallbladder. Report of Two Cases and a Review of the Literature.” Cancer 50, no. 6 (1982): 1166–1170. doi:10.1002/1097-0142(19820915)50:6<1166::AID-CNCR2820500622>3.0.CO;2-L.
