Symptom Finder - Treatment of Cutaneous Drug Reaction
CUTANEOUS DRUG REACTION (In all cases identify and withdraw offending drug)
Localized:
1. Calamine lotion.
2. Topical corticosteroids such as triamcinolone acetonide 0.1% cream (Kenalog): apply tid to affected areas
3. Diphenhydramine (Benadryl): 25–50 mg qid.
Generalized Mild–Moderate:
1. Diphenhydramine (Benadryl): 25–50 mg qid.
2. Prednisone: 40–60 mg daily and taper over 3- to 6-week period.
3. Topical corticosteroids as above.
Generalized–Severe:
1. Epinephrine: 0.01 mL/kg of 1:1,000 solution SC q2–3hrs or sooner.
2. Dexamethasone (Decadron): 4–12 mg IV q12hrs.
3. Diphenhydramine (Benadryl): 50 mg IM or IV q4hrs PRN.
Localized:
1. Calamine lotion.
2. Topical corticosteroids such as triamcinolone acetonide 0.1% cream (Kenalog): apply tid to affected areas
3. Diphenhydramine (Benadryl): 25–50 mg qid.
Generalized Mild–Moderate:
1. Diphenhydramine (Benadryl): 25–50 mg qid.
2. Prednisone: 40–60 mg daily and taper over 3- to 6-week period.
3. Topical corticosteroids as above.
Generalized–Severe:
1. Epinephrine: 0.01 mL/kg of 1:1,000 solution SC q2–3hrs or sooner.
2. Dexamethasone (Decadron): 4–12 mg IV q12hrs.
3. Diphenhydramine (Benadryl): 50 mg IM or IV q4hrs PRN.
