Pathology definition - Secondary Hyperparathyroidism
Secondary hyperparathyroidism may occur due to chronic renal failure. Patient may present with increased in the serum alkaline phosphate. Besides that, there will be metastatic calcification of the soft tissue and diffuse osteoclastic of the bone disease.
hypocalcemia, increased in parathyroid hormone and increases in serum phosphate. There will be decreased in the 1, 25, OH2 D3 production due to the kidney failure which will lead to decreased in the absorption of the calcium by the interstitium. This will lead to hypocalcemia and increased in the parathyroid hormone due to increased in the excretion of the calcium from damaging kidney.
The treatment will focus on the supplements of the vitamin D and calcium and removal of the abnormal gland surgically.