Infectious Disease definition - Bacillary Dysentery
Bacillary dysentery
Bacillary dysentery is associated with gram negative rod shigella which consists of mainly shigella dysenteriae, shigella sonnei, shingella boydii and shingella flexneri. Shingella dysenteriae may produce shiga toxin which may lead to hemolytic uremic syndrome ( serious condition). Shingella is lactose non fermenter.
Bacillary dysentery may present with symptoms and signs such as abdominal cramp, mucus and blood in the stool, diarrhea and fever.
Laboratory investigation may include stool cultures.
Bacillary dysentery will be transmitted mostly through fecal oral spread. It is associated with poor personal hygiene and poor sanitation. Shingella may carry a few virulence factors such as endotoxin and shiga toxin. Shiga toxin may lead to the death of endothelial cell as a result of the cleaves of the 28ds RNA by shiga toxin itself. The death and destruction of the cells may lead to host inflammatory response. The invasion process of Shingella begins with the invasion through the intestinal M cells. This will follow later by the escapes of the Shingella from the endosomes and repilcates itself in the cytoplasm and finally spread to enterocytes.
Bacillary dysentery is treated with antibiotic and supportive treatment. Antibiotic may include trimethoprim and ciprofloxacin which supportive treatment inlcude fluid and electrolyte replacement therapy.
References
1.Felsen, Joseph. "Bacillary Dysentery, Colitis and Enteritis." Bacillary Dysentery, Colitis and Enteritis. (1945).
2.Labrec, Eugene H., et al. "Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery." Journal of Bacteriology 88.5 (1964): 1503-1518.
Bacillary dysentery is associated with gram negative rod shigella which consists of mainly shigella dysenteriae, shigella sonnei, shingella boydii and shingella flexneri. Shingella dysenteriae may produce shiga toxin which may lead to hemolytic uremic syndrome ( serious condition). Shingella is lactose non fermenter.
Bacillary dysentery may present with symptoms and signs such as abdominal cramp, mucus and blood in the stool, diarrhea and fever.
Laboratory investigation may include stool cultures.
Bacillary dysentery will be transmitted mostly through fecal oral spread. It is associated with poor personal hygiene and poor sanitation. Shingella may carry a few virulence factors such as endotoxin and shiga toxin. Shiga toxin may lead to the death of endothelial cell as a result of the cleaves of the 28ds RNA by shiga toxin itself. The death and destruction of the cells may lead to host inflammatory response. The invasion process of Shingella begins with the invasion through the intestinal M cells. This will follow later by the escapes of the Shingella from the endosomes and repilcates itself in the cytoplasm and finally spread to enterocytes.
Bacillary dysentery is treated with antibiotic and supportive treatment. Antibiotic may include trimethoprim and ciprofloxacin which supportive treatment inlcude fluid and electrolyte replacement therapy.
References
1.Felsen, Joseph. "Bacillary Dysentery, Colitis and Enteritis." Bacillary Dysentery, Colitis and Enteritis. (1945).
2.Labrec, Eugene H., et al. "Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery." Journal of Bacteriology 88.5 (1964): 1503-1518.