Almost exclusively a drug reaction, 1–3 weeks from administration. The most frequent offenders are
antibiotics (especially trimethoprim-sulfamethoxazole and other sulfonamides, but also aminopenicillins,
quinolones, and cephalosporins); anticonvulsants (including phenobarbital, phenytoin, valproic acid, and
carbamazepine), and finally nonsteroidal antiinflammatory drugs, allopurinol, and even
corticosteroids. HIV patients have greater risk of Toxic Epidermal Necrolysis, and often tend to be younger. This may be related to their increased use of sulfonamides. Finally, Toxic Epidermal Necrolysis has been reported in systemic lupus erythematosus or acute graft versus host disease. Infections with herpesvirus,
Mycoplasma pneumoniae, or Yersinia may also occur in Stevens Johnson Syndrome, but even more in Erythema Multiforme.
antibiotics (especially trimethoprim-sulfamethoxazole and other sulfonamides, but also aminopenicillins,
quinolones, and cephalosporins); anticonvulsants (including phenobarbital, phenytoin, valproic acid, and
carbamazepine), and finally nonsteroidal antiinflammatory drugs, allopurinol, and even
corticosteroids. HIV patients have greater risk of Toxic Epidermal Necrolysis, and often tend to be younger. This may be related to their increased use of sulfonamides. Finally, Toxic Epidermal Necrolysis has been reported in systemic lupus erythematosus or acute graft versus host disease. Infections with herpesvirus,
Mycoplasma pneumoniae, or Yersinia may also occur in Stevens Johnson Syndrome, but even more in Erythema Multiforme.