FUO / fever of unknown origin in adults is most commonly due to infection, either closed space (abscess) or disseminated (malaria, tuberculosis, HIV, endocarditis, fungemia). Other less common causes include cancer (particularly lymphomas, hypernephromas, hepatomas, and hepatic metastasis of extrahepatic tumors); autoimmune diseases (collagen vascular diseases and vasculitis); and drug reactions. Patients with iatrogenic fever often have temperature/pulse dissociation, appear well in spite of high fever, and have other allergic signs, like skin rash or eosinophilia.
The causes of an essential fever
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